Rapid Response Vaccines Against Emerging or Re-Emerging Viruses (RFT-539)
Scientists at NDSU have developed a novel method for producing an inactivated virus by selectively destroying the RNA of an RNA virus while maintaining the integrity of the viral membrane. Then method has been demonstrated for porcine epidemic diarrhea virus (PEDV). PEDV emerged in the U.S in 2013 and spread rapidly to all the major swine production states. In 2014, PEDV was responsible for the death of a quarter of the U.S. swine population, leading to an industry loss of $540 million in 10 months. After pigs were vaccinated, no virus was detected in the fecal matter at necropsy or after the primary vaccination and boosters, indicating that both vaccines viruses were not amplified or shed in vaccinated animals. Similarly, no microscopic or IHC lesions were detected in these pigs in intestinal, heart, spleen and lung tissues. Therefore, both vaccine development approaches were safe and induced no side effects. (Figure shows our Vaccine 2 vs. another Vaccine 1 and control).
- Allows rapid preparation of a vaccine to a new outbreak or a mutated membrane strain of virus
- Improves maintenance of the original integrity of the viral membrane so solicited antibodies from the inactivated virus will be more effective against the active virus
- Allows complete destruction of the genetic material of the virus and inactivation of its infectious capability
- Allows integrity of the membrane coat to solicit and immune response to destroy future infection by active virus
- Vaccination of the pigs with the vaccine candidates induced strong virus neutralizing antibody responses in the group immunized with the heat+ Rnase treated virus
This technology is patent pending with fully preserved US patent rights and is available for licensing/partnering opportunities.
Henry Nowak, Technology Manager
NDSURF Tech Key RFT, 539, RFT539
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