Rapid Response Vaccines Against Emerging or Re-Emerging Viruses (RFT-539)

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Invention Summary

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Scientists at NDSU have developed a novel method for producing viral vaccines by selectively destroying the genetic material while maintaining the structural integrity. The method has the combined advantages of inactivated and attenuated vaccines. The method has been demonstrated as effective for porcine epidemic diarrhea virus (PEDV) but is applicable to other viruses. PEDV emerged in the U.S in 2013 and spread rapidly to all the major swine production states. In 2014, PEDV was responsible for the death of a quarter of the U.S. swine population, leading to an industry loss of $540 million in 10 months. In pigs that were administered the experimental vaccine and challenged with virulent virus, the challenge virus was not detected in fecal matter, indicating 100% protection in the vaccinated 3-week-old pigs (Figure shows antibody responses, viral loads and protection against microscopic lesions by our vaccine compared to unvaccinated animals). Similarly, no microscopic or IHC lesions were detected in vaccinated pigs in intestinal, heart, spleen and lung tissues. Therefore, the vaccine development approach was both safe and highly effective.

Benefits

  • Allows rapid preparation of a vaccine within weeks, in response to a new outbreak or a mutated strain of virus
  • Maintains integrity of the viral structure so antibodies elicited from vaccination will be more effective against the contemporary virus
  • Allows destruction of the genetic material of the virus, diminishing its infectious capability
  • Vaccination of the pigs elicited strong virus neutralizing antibody responses, eliminated viral replication and protected against intestinal pathology, while being completely safe

Patents

This technology is patent pending with fully preserved US patent rights and is available for licensing/partnering opportunities.

Contact

Henry Nowak, Technology Manager
hnowak@ndsurf.org
(701)231-8173

NDSURF Tech Key RFT, 539, RFT539

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