Biology & Medicine
Scientists at NDSU have developed a flexible, modular, bone scaffold for filling large bone gaps and accelerating bone growth with various additives, such as nutrients, cytokines, therapeutics and minerals incorporated into the scaffold. The scaffold is made of a clay and a polymer.
Scientists at North Dakota State University have developed an anti-cancer compound that indirectly targets the over-expression of COX-2, with potential to treat multiple cancer types
Targeted Delivery and Rapid
NDSU Scientists have developed a liposome-based delivery method with potential to reduce chemotherapy side effects while maintaining or even increasing cancer drug efficacy. The liposome is stabilized in the bloodstream using polyethylene glycol (PEG) and remains stable in the vicinity of healthy cells. However, upon arrival at a tumor the liposome rapidly disintegrates, releasing its contents to be taken up by tumor cells. This disintegration is triggered by conditions found in the tumor extracellular matrix (ECM), specifically the reducing conditions and the presence of Matrix Metalloproteinase 9 (MMP-9). As a result, these liposomes can carry drugs and imaging agents to tumors, releasing them so that a high concentration is available for rapid uptake into tumor cells, and reducing the amount of time these agents spend in the circulatory system or in the vicinity of healthy cells. A reduction in tumor growth was observed using this technology to deliver drugs in a mouse model of pancreatic cancer.
Scientists at NDSU have developed a monoclonal antibody that inhibits activation of the receptor for advanced glycation end products (RAGE). The antibody binds the V-domain to block activation of RAGE by its ligands. This domain is capable of binding to multiple structurally and functionally diverse ligands, all of which trigger signal transduction by RAGEs cytosolic domain, and results in sustained inflammation that is associated with diabetes, cancers, Alzheimer's, multiple sclerosis, and other diseases associated with chronic inflammation. As a result, the anti-RAGE monoclonal antibodies have potential to treat a wide variety of diseases.
This technology is a monoclonal antibody recognizing the V domain of the receptor for advanced glycation endproducts (RAGE). RAGE is emerging as a biomarker in many human diseases such as diabetes, cancer and Alzheimer's disease. In animal models, antibodies against RAGE have shown to reduce RAGE deleterious signaling. RAGE is a cell-surface receptor that is activated by several ligands. RAGE is therefore a suitable target for monoclonal antibodies. We have generated monoclonal antibodies with the aim of blocking RAGE/ligand interaction and decreasing RAGE deleterious effects in several human diseases.
NDSU engineers have developed an improved design and material for Total Ankle Replacements (TARs) that features an inverted design, in which the concave portion of the joint is on the bottom, and the convex on the top. This inverted design and the mode of assembly and implantation offers several benefits to surgeons and patients.
Novel PEGylated Compounds and Process for Making Antifouling/Biocompatible Materials Surfaces having non-fouling characteristics are of great interest for the development of advanced materials in many different applications. In medical device applications, protein attachment can cause any number of unwanted immune reactions when exogenous materials are implanted into biological systems. Materials developed with polyethylene glycols, often referred to as PEGylated materials, are of great interest due to their protein resistance and nontoxic properties. One of the most widely used biomaterials is Polyurethane, due to its biocompatibility and its mechanical properties. Researchers at NDSU have developed a new class of PEGylated polyurethane materials using a novel process which is much more effective than traditional procedures. The resulting compounds are novel siloxane-PEG copolymers having terminal amine functionality and a backbone of siloxane having a varied number of pendant hydrophilic PEG chains. The low surface energy siloxane can aid in bringing PEG chains to the surface, and the terminal amine functionality can be bound into the polyurethane by reaction with isocyanate. Therefore, the surface of the material will be amphiphilic while the underlying polyurethane bulk will give toughness to the system. This approach allows for precise control over the number of hydrophobic PEG chains, siloxane and PEG chain lengths, and terminal amine functionality.
Scientists at North Dakota State University have developed a method to confer dual-action and broad-spectrum (gram +, gram -, and yeast) anti-microbial properties into polymers and coatings. The anti-microbial components are quaternary ammonium salts (QAS) and silver. The QAS component is attached to polysiloxane backbone. it may be strongly attached to provide a contact-active anti-microbial, or may be gradually released and leachable. Silver may also be integrated, and the NDSU technology enables silver to be efficiently incorporated just into the outer portion of a surface by dipping into an appropriate silver solution. This means the silver need not be included throughout a polymer or coating layer, but instead can be positioned right at the surface where essentially all the silver is available, and provides a rapid anti-microbial effect once the surface is hydrated.The resulting materials include both a rapidly acting soluble anti-microbial component, and a longer lasting contact-active component to kill microbes that make direct contact with the material.